England head coach Steve Borthwick has kept three uncapped players in his trimmed 29-man squad for their opening Six Nations match against Scotland on Saturday.
Jack Walker, Ollie Hassell-Collins and Fin Smith are the three new faces who keep their places, but Toulouse flanker Jack Willis, Sale lock Jonny Hill, and props Joe Heyes and Bevan Rodd were excluded.
In the backs centre Guy Porter, scrumhalf Alex Mitchell and winger Cadan Murley were also left out.
England will be without centre Henry Slade who has not recovered after a hip injury earlier this month, while Dan Kelly and vice-captain Courtney Lawes are also on the injury list.
On Friday, it was announced that fullback Elliot Daly would miss the entire Six Nations championship because of a hamstring injury.
Hooker George McGuigan withdrew from the squad last week and forward Luke Cowan-Dickie is set to miss the Scotland match with an ankle problem.
Full Squad
Forwards:Ollie Chessum (Leicester Tigers, 5 caps)Dan Cole (Leicester Tigers, 95 caps)Ben Curry (Sale Sharks,1 cap)Alex Dombrandt (Harlequins, 9 caps)Tom Dunn (Bath Rugby, 3 caps)Ben Earl (Saracens, 13 caps)Ellis Genge (Bristol Bears, 43 caps)Jamie George (Saracens, 72 caps)Nick Isiekwe (Saracens, 8 caps)Maro Itoje (Saracens, 62 caps)Lewis Ludlam (Northampton Saints, 14 caps)David Ribbans (Northampton Saints, 3 caps)Sam Simmonds (Exeter Chiefs, 18 caps)Kyle Sinckler (Bristol Bears, 56 caps)Mako Vunipola (Saracens, 74 caps)Jack Walker (Harlequins, uncapped)
Backs:Owen Farrell (Saracens, 101 caps) (captain)Tommy Freeman (Northampton Saints, 3 caps)Ollie Hassell-Collins (London Irish, uncapped)Ollie Lawrence (Bath Rugby, 7 caps)Max Malins (Saracens, 14 caps)Joe Marchant (Harlequins, 13 caps)Fin Smith (Northampton Saints, uncapped)Marcus Smith (Harlequins, 17 caps)Freddie Steward (Leicester Tigers, 17 caps)Manu Tuilagi (Sale Sharks, 50 caps)Jack van Poortvliet (Leicester Tigers, 7 caps)Anthony Watson (Leicester Tigers, 51 caps)Ben Youngs (Leicester Tigers, 121 caps)
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