CryoEM

Using UT Southwestern's Cryo-Electron Microscopy Facility, researchers have captured images of an enzyme for Wnt lipidation, which is pivotal to human development and cancer and crucial for Wnt signaling activation. The findings, reported…

Only one thousandth of a milligram of the bacterial botulinum toxin is necessary to kill a living organism. The toxin unfolds its lethal effect by preventing the release of neurotransmitters at the point where nerve cells attach to muscles,…

Previously, it has been impossible to capture the high-resolution images of nitrogenase, the only enzyme capable of reducing nitrogen into ammonia, during catalytic action. Now, for the first time, researchers at the University of…

Pharmaceuticals, plastics, and other industries use enzymes to help synthesize molecular feedstocks. Enzymes taken straight from microbes such as bacteria are often not optimal for industrial use; one issue is that they often do not survive…

Imaging at near-atomic resolution of a key immune protein commonly known as STING has revealed a previously unrecognized binding site that appears to be pivotal for launching immune attacks, UT Southwestern scientists report in a new study.…

Researchers at the Okinawa Institute of Science and Technology Graduate University (OIST) have revealed how poxviruses build their scaffold -- a temporary protein coat that forms and disappears as the virus matures. Reporting today in…

When something goes wrong during DNA replication, cells call their own version of 911 to pause the process and fix the problem -- a failsafe that is critical to maintaining health and staving off disease. Now, scientists at Van Andel…