Checkpoint

Over the last decade, immune checkpoint blockers, or ICBs, have revolutionized treatment for various advanced cancers, including melanoma, the most aggressive skin cancer that was considered largely incurable not long ago. However,…

University of Minnesota researchers and their collaborators at the National Cancer Institute (NCI) investigated the role of a new intracellular checkpoint gene in regulating T-cell function against solid tumors. Known as CISH, the team…

Researchers in the laboratory of Yulia Nefedova, M.D., Ph.D., at The Wistar Institute and collaborators at Jubilant Therapeutics Inc. have uncovered a novel mechanism by which protein arginine deiminase 4 (PAD4) in neutrophils promotes…

Global smartphone player Xiaomi has fixed some bugs that were identified in its mobile payment mechanism by cyber security researchers, Check Point Research (CPR) said. Left unpatched, an attacker could steal private keys used to sign…

Immunotherapies, such as immune checkpoint inhibitors, have transformed the treatment of advanced stage cancers. Unlike chemotherapies that kill cancer cells, these drugs help the body's immune system to find and destroy cancer cells…

The tractor-trailer at the center of a human-smuggling attempt that left 53 people dead had passed through an inland U.S. Border Patrol checkpoint with migrants inside the sweltering rig earlier in its journey, a U.S. official said…

An Iditarod sled dog was found safe after disappearing from a checkpoint in the race three months ago and covering nearly 150 miles, the Iditarod Trail Committee said Saturday. Musher Sebastien Dos Santos Borges…

Researchers at The University of Texas MD Anderson Cancer Center have developed an ultrasound-guided cancer immunotherapy platform that generates systemic antitumor immunity and improves the therapeutic efficacy of immune checkpoint…

Researchers at The University of Texas MD Anderson Cancer Center have identified a novel strategy to reduce immune-related adverse events from immunotherapy treatment by targeting the cytokine interleukin-6 (IL-6). The study, published…

Fighting cancer and chronic disease is tiring work for the immune system. When T cells are engaged in this kind of lengthy battle, they can become exhausted, or unable to function properly. One immunotherapy that revitalizes these cells by…