Moderna says Covid booster better against omicron BA.5, triggers immune response against BQ.1.1

Moderna’s new Covid booster triggered a stronger immune response against omicron BA.5 and also appears to work against the emerging BQ.1.1 subvariant, according to the company.

Moderna, in clinical trial data published Monday, found that the new booster triggered five times more antibodies against omicron BA.5 than the old vaccines in people with prior Covid infections. The boosters triggered more than six times more antibodies against BA.5 in people without prior infections.

The study examined 500 people ages 19 to 89 who received the new booster. It is the first human data Moderna has released on the boosters.

Moderna said it also found the new booster triggered robust immune response against omicron BQ.1.1, an emerging Covid subvariant in the U.S. However, the response was not as strong against BQ.1.1 compared to BA.5. The antibody levels were about five times lower against BQ.1.1.

The Food and Drug Administration asked Moderna and Pfizer to develop the boosters against omicron BA.5 over the summer when it was dominant. But other omicron subvariants are pushing out BA.5 just couple months after U.S. health regulators cleared the boosters.

Omicron BA.5 now makes up 29% of new infections in the U.S., while the subvariants BQ.1 and BQ.1.1 represent 44% of new cases in the U.S., according to data from the Centers for Disease Control and Prevention. U.S. health officials have said the boosters should provide protection against the BQ subvariants because they are descended from BA.5.

Pfizer also released data earlier this month indicating that the boosters provide better protection against omicron BA.5 than the old shots.

Public interest in data on the boosters is high because the FDA authorized them without direct human data on how they perform. The agency relied instead on clinical trial data from a similar booster that targeted omicron BA.1, the original version of omicron that caused the massive wave last winter.

Pfizer and Moderna were originally developing boosters against omicron BA.1, but the FDA asked them to switch gears and target BA.5 instead as the subvariant became dominant over the summer. The sudden change did not leave enough time for the companies to launch clinical trials and submit data on the BA.5 boosters before authorization.

Two independent studies from Columbia and Harvard found that the boosters did not do a much better job against omicron BA.5. The FDA pushed back against those studies, arguing that they were too small to draw definitive conclusions about the shots.

The new boosters, called bivalent vaccines, target both omicron BA.5 and the original version of Covid that emerged in China in 2019. The old shots, called monovalent vaccines, only target the original version of Covid.

The effectiveness of the old shots against infection and mild illness has declined dramatically as the virus mutated further and further away from the original strain. The old shots still generally provide protection against severe illness, though this protection is also declining.

U.S. health officials hope the new boosters will help head off another massive wave of disease this winter.