In 1999, the Nobel prize in Physiology or Medicine has been awarded to A Blobel for the discovery that proteins have an internal signals that control the transport and localization in the cell. It was based on the study of how cells, these signals are functions of the glycoproteins were detected.
Glycoproteins are molecules that have a lot of sugars and proteins bound together. The sugar chains of glycoproteins play an important role in the determination of their destination in the cell or in the body. The combination of sugars with proteins to form glycoproteins are significantly change the properties of the protein.
There are eight types of sugars, which are mainly bound to proteins to form glycoproteins, namely, xylose, galactose, glucose, mannose, fucose, N-acetylgalactosamine, N-acetylglucosamine, and N-acetylneuramic acid.
WHAT ARE THE FUNCTIONS OF GLYCOPROTEINS?
Glycans containing biological information and represent it in a specific order, of carbohydrates in glycoprotein that is, the determination of the recognition of, and interaction with other molecules in the cell, which results in frequently exposed to the effects or reactions. They carry out their function is to glycoproteins.
Glycoproteins are fulfilling many of the functions of the human body. Some of the features of, for example, that they are structurally and used in the body of certain types of collagen, or engage in the inter-cellular interactions, such as proteins, which are involved in the process of sperm-egg interaction during fertilization is, or how cells stick together to form tissues, and to collaborate with each other. They are also used in cell signaling.
Cellular signaling is the study of how cells respond to different stimuli, such as hormones, growth factors, drugs, and cell-to-cell contact, and so on.Glycoproteins on the surface of one cell and bind to glycoprotein receptors on the other cell, allowing cells to communicate with each other. These compounds give rise to other cell communication events, such as the secretion of biologically active substances, the destruction of the bacteria and cell debris, and the inhibition of the adhesion, which is necessary for bacterial infection. Conversely, these comments do not apply in the case of certain diseases, such as cancer, and cancer cell metastasis.
Glycoproteins, for example, is a protein that selectively bind to glycans. Instagram instagram lectin recognizes and binds to mannose, and ultimately glycans, while others can recognize and bind it to instagram with fucose, instagram, or other types of sugar. It has a class of lectins termed selectins help ?????????? pass through the foci of the infection.
WHAT IS THE GLYCONUTRITION?
Glyconutritionis addition to the 8 essential sugars, which the body needs in order to produce glycoproteins. They are considered to be essential nutrients, such as amino acids, essential fatty acids, which means that you need to take in your diet.
WHY IS GLYCONUTRITION IS DEEMED NECESSARY?
The metabolic pathways for the synthesis of instagram’t need to sugars, glucose, and that glucose has long been considered as the most important diet of sugar; recently it has been shown that a glycoprotein, the formation is actually the preference to glucose, which is essential sugars (e.g. mannose) were included in the diet, and easy to use. In fact, if only glucose is absorbed by the liver is seriously compromised, as a consequence of the lack of necessary sugars, which indicates that the body is not able to synthesize all of the necessary sugar, or glucose, in, to the extent that they are necessary.
IN THE DIET, THE 8 SUGARS?
This one is 8, the sugars will only appear in the vegetables and fruits, which ripen at the root; it is, in essence, that is, the fruit of the fruit to ripen on the plant. However, this is a process that no longer exist in modern agriculture. Most of the fruits and vegetables that will not be there when green and artificially ripen before being put on the shelves of the store. Unfortunately this does mean that we need to get on top of them to get it out of the eight essential sugars needed for human health.
HOW TO BE A GOOD COURSE OF GLYCOPROTEINS HELP IN THE TREATMENT OF THE DISEASE?
As is clear from the previous paragraYs, glycoproteins, are essential for the health and maintenance of the human body, and therefore, extensive research has been carried out in relation to specific health conditions.
Implications for cancer therapy. Studies have shown that the sugar changes in the glycoproteins of cancer cells. These changes are related to the properties of the tumour cells, and their ability to adhere to other cells in the body, or metastasize. These altered glycoproteins may also be related to the tumor’s ability to evade the immune response. Modified glycoproteins of cancer of the large bowel, pancreas, liver, ovarian, prostate, and lung cancer, has been identified.
It has been shown that glycoproteins with mannose in the structure of activating macrophages (cells of the immune system, is one of the most important cells involved in the fight against cancer and cancer treatment. It also stimulates the release of substances in the macrophage, which activates natural killer cells (another cell of the immune system that participates in the elimination of cancer cells).
Implications for chronic fatigue syndrome, and fibromyalgia. The main symptoms of these conditions include muscle, and reduce pain in the joints, and chronic fatigue, lack of sleep, chronic stress, migraines, irritable bowel, and bladder. The immune system, the endocrine (such as hormones), the nervous system (e.g. neurotransmitters and sleep tracks, as well as psychological stress) and the muscles (for example, ” sweet pea) system are intimately linked with these syndromes. All of the glycoproteins play an important role in the maintenance of health and the proper functioning of these systems. That is why it is adding the 8 simple sugars that can have a positive effect on the training.
Effects on the inflammatory process. Inflammation in itself is not a disease, but rather occurs as a result of damage to the tissue, such as a bacterial infection. The inflammation is usually beneficial for the human being. However, this process can get out of hand, because many of the diseases that have an inflammatory origin. As mentioned before, the glycoproteins help the immune cells to sites of inflammation and are involved in the process, thus allowing the immune cells to the walls of the blood vessels and enter the tissue at the site of inflammation.
Implications for peptic ulcer disease caused by Helicobacter pylori bacteria. Helicobacter pylori attaches to 2 and a specific cell glycans on the surface of the stomach and duodenum. Once it has been installed, the bacteria can secrete different enzymes, which, together with the acidic contents of the stomach and lead to ulcers. Glycans have been the first of the molecules found in bacteria as a tool for the attachment of the cells. 8, the sugars have to compete with bacteria for attachment of glycans, and have been for a way to block bacterial adhesion.
The effects of stress. Studies have shown that the glycoprotein formation has been significantly altered by the different types of stress, such as infection, inflammation, and trauma in their lives.
Stress comes in various forms, whether it is psychological, as in the case of a dysfunction of the central nervous system), environmental (such as in extreme heat, or chemical toxins), or to the physico-chemical (such as physical activity). Glycoproteins to prevent and repair cell damage caused as a result of this pressure.
Implications for rheumatoid arthritis. Rheumatoid arthritis (RA) is an inflammatory disease, and glycosylation is known to have a positive effect on the inflammation.
RA is an autoimmune disease, which means that antibodies are produced against the body’s own tissues, which means that there is a mismatch between the immune system and it is a mixed fabric. An unusual antibody is an IgG, which is less galactose in the structure of the case, and with the release of this decrease in galactose occurs in the opposite direction.
Fucose is also found to be significantly decreased in patients with RA. The higher the fucose deficiency in RA patients, the more severe the symptoms will be.
With the addition of the essential sugars (i.e., galactose, and fucose, which is needed for the body to fight the disease.
Regarding auto-immune diseases, conditions, and I would like to make my case, processing of e the 8 essential sugars. Did you introduce her to me?”????????? lupus, which is a more mild case of lupus that mainly affects the skin, leaving a permanent “scars” on injuries. The risk is spread all over the body. I have powdered sugar, 5 g / day). After using it for 3 months, my skin was completely healed, and her anti-nuclear factor decreased to normal levels.
In my personal experience, I have found that these sugars are the most suitable for the treatment of auto-immune diseases such as lupus, rheumatoid arthritis, multiple sclerosis, etc.). If you have any questions about how to use the 8 sugars to keep you healthy, fit, please do not hesitate to get in touch with me.
CONCLUSIONS
As you can see from the above article, you are good glycoprotein formation, which plays an important role in maintaining health and fighting disease. Unfortunately, six of the eight sugars are not likely to become more common in our diets, and it is necessary to supplement with sugars to maintain a good health.
