The vaccine maker said the decision to focus on the current vaccine, mRNA-1273, was driven in part by how quickly the recently discovered variant is spreading. The company still plans to develop a vaccine specifically to protect against Omicron, which it hopes to advance into clinical trials early next year.
“What we have available right now is 1273,” Dr. Paul Burton, Moderna’s Chief Medical Officer, said in an interview. “It’s highly effective, and it’s extremely safe. I think it will protect people through the coming holiday period and through these winter months, when we’re going to see the most severe pressure of Omicron.”
The company said a two-dose course of its vaccine generated low neutralizing antibodies against the Omicron variant, but a 50 microgram booster dose increased neutralizing antibodies against the variant 37 fold. A higher, 100 microgram booster dose of the same vaccine drove antibody levels even higher – more than 80 times pre-boost levels.
The data, which has not yet been peer reviewed, tested blood from people who had received the vaccine against a pseudovirus engineered to resemble the Omicron variant. It is similar to data discussed last by top U.S. infectious disease expert Anthony Fauci.
Burton said it would be up to governments and regulators to gauge whether they want the enhanced level of protection that a 100 microgram dose might confer.
The company said that the 100 microgram dose was generally safe and well tolerated, although there was a trend toward slightly more frequent adverse reactions.
Moderna also tested the vaccine’s effectiveness compared to its prototype boosters that target multiple previous variants of concern, and said the results were similar.
U.S. regulators authorized the 50 microgram booster of Moderna’s vaccine in October. The first two shots of Moderna’s vaccine are both 100 micrograms.
Both the Moderna and the Pfizer/BioNTech vaccines have been linked to rare cases of heart inflammation, particularly in young men. Several studies have suggested that Moderna’s vaccine is likely to cause the heart inflammation at a higher rate.
Omicron, a highly contagious variant first detected last month in southern Africa and Hong Kong, has raced around the globe and been reported in 89 countries, the World Health Organization said on Saturday.
It said the number of Omicron cases is doubling in 1.5 to 3 days in areas with community transmission, but noted that much remains unknown about the variant, including the severity of the illness it causes.
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